What is the meaning of i casi umani? - Question about Italian

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Definition of i casi umani it's like someone that has no chance at all to understand the world or people in general, someone that is a "lost cause" |We usually use this expression in Italian when we are not able to get along with someone, for example if they have attitude or they act badly or weirdly. In English you can say “lost cause” but I would say more “something’s wrong with him/her”
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